If a creature is transformed into another creature (say, a human into a dog), then that creature will become more and more accustomed to the new form until a point is reached where reversing the spell is impossible. A second transformation is possible, but the creature will have to go through the whole process again.
An ancient, psuedo-immortal race has been manipulating something important (politics, religion, economics, etc.) for centuries. Hardly anyone is aware of them, let alone their goals.
In a high canyon in the mountains, the players find a skeleton in a cage suspended from a pole. A few miles further, they find another, and a third contains a partially rotten corpse. The fourth contains a living man who looks as if he hasn't eaten in days. Turns out to be the local way of punishing criminals.