You type the command into the console. "Insufficient Guineapigs" the computer responds. Baffled, you retype the command. "Insufficient Guineapigs" the computer replies again. You decide you should start smaller, with a simpler command. "Insufficient Guineapigs"
What does cycling the spaceship's airlock have to do with a now-extinct Peruvian rodent?
In some virtual forums going AFK is the equivalent of passing out drunk on the couch at a fraternity party. Everyone from hackers to everyday participants will take shots at you, and you can expect your avatar to look very different when you get back. Hopefully you will notice quickly.
Draw the party together as debtors to the local lord, king, head of the thieves guild, or mercenary clan, who is forcing them to work together to pay off their debts.
In your world the pantheon is a rotating system of formerly human individuals. You have been selected for god-duty for the next 2,000 years. How are you going to get out of this?
It has been said that within the mountains (or was it the darklands?) there dwells a fluffy creature of immense cuteness. This creature is so adorable that all who encounter it are filled with joy so great their mortal forms cannot contain it. And they explode. Several magic institutions are desperate to study the creature or better yet capture one to prove the theory of an elemental plane of "D'Awwww".
How Jayel became the proprietor of the Wanton Wench is more or less a hand-waved affair by the local officials. The facts known by 'upstanding' folk are that a fresh-faced young girl by the name of Jayel came into Gatewatch, disappeared, and reappeared the aged and stern woman she is today. The facts known by the night watch are a marked decrease in drug trafficking and battered women appearing on the streets. The fact known by Jayel is that she killed a man with her bare hands, and has never looked back.
A small band of squirrels seems to be fighting high up in a tree over a shiny nut-sized object. Can you retrieve the prize without scaring the squirrels into running off with it? If they do, can you manage to chase them down?
The players see a small shrine to the local nature deity just of the trail. Before they even approach it, they can smell the foul stench of rotting meat. If they inspect the shrine, they can see it has been desecrated by rotting organs in the last few days. There is no mistaking it for an obscure ritual, the organs are thrown everywhere, not left in specific places as in sacrifice.
If the players try to clean the shrine, they will soon find it has been boobytrapped to fling sharp splinters covered in the rotting gore in every direction. While only doing a few points of damage, they injured players will likely take sick soon unless they get medical attention.