In ancient China, women bind their feet for cosmetic reasons, resulting in them not able to walk without help and walking in a shuffling gait.
Possibly this can be modified such that people do it for less stupid reasons.
Disclaimer: This is NOT a racist remark since I'm Chinese myself and hence entitled to freely judge Chinese customs. NOT sexist either since I'm female as well.
A terrible teleportation incident makes inter-demihuman chimaera of all the PCs. Quoth Master Adams: 'I teleported home one night / with Ron and Sid and Meg / Ron stole Meg's heart away / and I got Sidney's leg.'