In ancient China, women bind their feet for cosmetic reasons, resulting in them not able to walk without help and walking in a shuffling gait.
Possibly this can be modified such that people do it for less stupid reasons.
Disclaimer: This is NOT a racist remark since I'm Chinese myself and hence entitled to freely judge Chinese customs. NOT sexist either since I'm female as well.
The PCs find a small green glass bottle, something can be seen writhing within the smoked glass. If the PCs open the bottle a repulsing form of life will pour forth and grow in size. A genderless beings of soft pliable purple flesh towers before the PCs, it has no detail, no distinguishing characteristics except for a narrow slit for a mouth that holds rows of inwardly curving teeth.