In ancient China, women bind their feet for cosmetic reasons, resulting in them not able to walk without help and walking in a shuffling gait.
Possibly this can be modified such that people do it for less stupid reasons.
Disclaimer: This is NOT a racist remark since I'm Chinese myself and hence entitled to freely judge Chinese customs. NOT sexist either since I'm female as well.
This really comes from an ancient Chinese novel. Imagine during the PCs' travels, they come to a place where the gender roles are completely reversed. What adventures will the PCs encounter in such a place?
A sentiment weapon that is very impressionable in terms of what is right and wrong, akin to a child. Currently, being ownerless, it is not very powerful. However, once it has found an owner, it can provide significant boosts to the wielder in an area or areas the wielder most desire. What adventures will this sentiment weapon go through? How will it develop itself in terms of power and personality?
Just off the road a man lies dead, pierced through the heart from behind by an expertly thrown and ornate dagger which remains in the body. A long strip of cloth torn from the man's shirt has been tied around his neck; on the tag end an unknown hand has written a cryptic inscription: "For Djaygo."
When you get to the next town, everyone is talking about a mercenary woman found slain in exactly the same fashion in her room at the inn where she was staying.