In ancient China, women bind their feet for cosmetic reasons, resulting in them not able to walk without help and walking in a shuffling gait.
Possibly this can be modified such that people do it for less stupid reasons.
Disclaimer: This is NOT a racist remark since I'm Chinese myself and hence entitled to freely judge Chinese customs. NOT sexist either since I'm female as well.
This really comes from an ancient Chinese novel. Imagine during the PCs' travels, they come to a place where the gender roles are completely reversed. What adventures will the PCs encounter in such a place?
A sentiment weapon that is very impressionable in terms of what is right and wrong, akin to a child. Currently, being ownerless, it is not very powerful. However, once it has found an owner, it can provide significant boosts to the wielder in an area or areas the wielder most desire. What adventures will this sentiment weapon go through? How will it develop itself in terms of power and personality?
A race of beings actually IS invunerable while in adolecence. They age, but cannot be killed. A miniority of the race (1 in 20) does not become invunerable, but rather becomes immortal at some point in thier adolecence, and ceases aging while being vunerable to death in all the normal ways. Another minority (also 1 in 20) Permanatly becomes invunerable after adolecence, but ages twice as fast as the race normally does. There is no known way to test for which of the three traits an individual manifests and the three traits cannot mix, as they are tied to the same gene, as it were.