In ancient China, women bind their feet for cosmetic reasons, resulting in them not able to walk without help and walking in a shuffling gait.
Possibly this can be modified such that people do it for less stupid reasons.
Disclaimer: This is NOT a racist remark since I'm Chinese myself and hence entitled to freely judge Chinese customs. NOT sexist either since I'm female as well.
This really comes from an ancient Chinese novel. Imagine during the PCs' travels, they come to a place where the gender roles are completely reversed. What adventures will the PCs encounter in such a place?
A sentiment weapon that is very impressionable in terms of what is right and wrong, akin to a child. Currently, being ownerless, it is not very powerful. However, once it has found an owner, it can provide significant boosts to the wielder in an area or areas the wielder most desire. What adventures will this sentiment weapon go through? How will it develop itself in terms of power and personality?
Near a major city, a mirror image of the place has appeared. This strange double is infested with hostile insectoid humanoids that appear to match the city folk in numbers and armaments. The humans’ diviners have determined that the secret of the city’s appearance can be found within the double’s college of magic, so heroes are needed to explore within this mirror city and discover what has drawn it from its distant realm. There isn’t much time to spare, as the bug folk find their mammalian counterparts unnatural and blasphemous, and plan to destroy them.