God has been slayed by a mortal man and his head is now worshipped and put on a pedestal. The PCs are hired to steal the head and bring it to a mystic that claims to have the power to revive God.
The PCs find a small green glass bottle, something can be seen writhing within the smoked glass. If the PCs open the bottle a repulsing form of life will pour forth and grow in size. A genderless beings of soft pliable purple flesh towers before the PCs, it has no detail, no distinguishing characteristics except for a narrow slit for a mouth that holds rows of inwardly curving teeth.
During a storm the PCs come upon a little boy that plays in the rain. Upon further inspection they discover that he has one eye and a long tongue lolling in its mouth. Spit dripping. It is a demon from beyond that can access our realm during storms, it eats all heads that are not its own, living and dead.
Moonlight shines down on the tranquil scene of a slumbering inn along one of the many roads that cross the land. Trees sway gently in the night air, and the stars twinkle brightly. All is quiet as the PCs snore away, a fine tendril of smoke curlsrnunder their door. The tavern is on fire! This is particularly bad news if the PCs own any horses - the screaming they hear is probably from their mounts! Panicky people are rushing about with buckets of water, trying to tame the flames. The fire fighting effort is not very coordinated as everybody is either hungover or still drunk, including the PCs. Hurry!
The PCs find a strange helmet, when donned it will take control of that PC and speak and act trough him/her. It explains that it is benevolent and needs their help in a quest and that it will stop possessing the PC when the task is done. Great if a player is gone for a number of sessions.
As the PCs cross a brigde/tree over a deep river they see the glimmer of gold and jewels lying at the bottom. At further inspection they notice that it is the skeleton of a man still holding on to a sack of treasure. Will the PCs try to dive to get it? What killed the man? Did he simly not let go of the bag he could not swim to the surface with? What cleansed his bones so? Are there flesh-eating beings that dwell in the deep? Can the players resist the chanse of being wealthy for once?
A little way up the narrow valley, before they reach the woods, the PCs notice the squat, tumbledown buildings by the riverside. They are hardly big enough for a human to stand in, and the complex cogs and shafts that occupy the central cavity of one of the buildings are perplexing. What were these buildings? And how safe are they to explore?
Alternatively a desolate place is the perfect setting for a derelict chapel or croft. There needn't be any actual physical encounter involved, but it adds atmosphere to a place to see its dead history. For instance, in the Outer Hebrides there are whole deserted villages which were razed to the ground by the English during the Clearances. Such stories give a setting authenticity and character.