A long time ago. Final fantasy III came out with a new approach to learing magic. The characters would be equipped with espers(magical beings) and as they fought more battles, they would learn spells from the espers. What if a similar approach to learning magic was applied to a P&P rpg?
You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)