Consider the idea of spontaneous genesis of life, as used to be belived. What strange kinds of life might arise from modern substances? What kind of vermin would a landfill produce, or an oil spill on the ocean?
A demon who isn't some hideous creature bent on consuming souls, bu is, in fact, a likable chap who enjoys having pleasant chats with people - trying to talk them into becoming his servants.
There is a certain kind of silver-coloured spider who's bite injects an addictive drug into the person that creates a sense of euphoria. Once bitten the PC has a 50% chance of being addicted to the spider's bite and will carry it around with him or her.Long term use leads to serious injury or death.At first the PC will just seem a bit slower or sleepier then normal.