If mana recovered slowly enough, and mages could pass it on freely between them, the ephemeral force would become a valuable trading commodity on its own.
What if a mage passes his powers on to his firstborn son, and a female mage to her first daughter, leaving the parent POWERLESS? A plain mortal, a sorcerer no longer, all wizardly might gone?
Or: what if a female wizard recieves the power of a mage who sires a child with her? Could lead to promiscuous witches and overly careful mages.
What if cancer is not an ailment if one has a will powerful enough, and knows what do do. What if one using the right techniques could control it and use it to become immortal, or to grow into something else?
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...
For those familiar with cantrips, you know they are minor acts of magic that have hardly any noticable effect on the world. For example a cantrip to make your food taste better won't heal you any more, or be any more nourishing, just won't make it so hard to get it down. A light cantrip certainly won't be able to blind or even distract anybody, but you might be able flash it to signal someone looking at the right spot.
What if children's nusery ryhmes were a form of cantrip? Like the "Rain, Rain, go away, come again another day." One child singing it wouldn't do more than spare her house a couple raindrops, but what if the whole village got together and was chanting in unison? Each one doing just a bit might actually be able to divert a whole storm...