Real world scientists have accidentally opened a tear in the fabric of reality, transporting their laboratory into the game world. Unable to repair and/or refuel their equipment in this (to their minds) primitive world they are now trapped.
The local band of 'nasties' (goblins / orcs / whatever) lives in relative peace with the local population.
Along come the PCs and go through their usual heroic monster bashing routine, wiping out the nasties and pinching all their stuff, then continue on their way.
Problem is, they don't kill ALL he nasties. The survivors want revenge and, after spending a few months recovering, start to take it in their own inimitable style (which is not unlike that of the PCs come to think of it).
Next time the PCs are in the area they find themselves VERY unpopular with the townsfolk.
A plague has hit the local area.
In humans it affects only the most vulnerable, the children and the very old, and even than it's little more than a summer cold. 24 hours of sniffles and then it's gone, barely noticeable really.
To sheep however it is fatal and the whole economy of the area is in serious trouble. If this keeps up the area could well be facing famine.
Somebody (enter the PCs) must find the rare herbs needed to make a cure.
A flower possibly in the plains or maybe all over that is always tilted towards a certain place. Sunflowers. Could possibly follow the sun or could be forever facing a certain position because of something that happened, either the air forcing it that way and it staying, the fire was so strong that the flowers faced away from it. It could be that in one spot a large fire was made or a fire war where many fire elementals were destroyed by the True Gods and radiating out from that point all of this flower is facing away from it so no matter where you are you always know where this place is by seeing which way the flower is facing away from.