A world where, instead of aging in years, the people age in knowledge. So, instead of dying once a general age was reached, they die once they achieve a certain amount of knowledge. A man could live forever if he never learned anything, or could die after reading a few choice books. Of course, the knowledge of the land would be regulated, like medical drugs.
Actually a real-world fungus, just heard about it. A fungus that tastes well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick, pains, vomiting, all the fancy stuff. Was really used to cure alcoholism. May be a joke or to make sure the heroes spend their time focused on the mission.