Beware of towns afflicted with Time Cancer.
For every second you progress through time, an infected town goes back 48 hours. Old buildings slowly become new, then incomplete, and finally just a frame and foundation, giant old trees turn to saplings, birds hatch into eggs.
one must not linger in a chrono-cancerous village for too long, before you know it you'll be a fetus. Tme cancer in unstoppable, no cure or treatment is knwn, it eats through the past until the inhabitants of a village turn into primordial protein ooze
A PC Conjurer or summoner, basically any mage whose sole purpose in life is summoning creatures to aid in battles and various situations, is cursed with a hex, and needs to find a way to undo the curse...before he goes mad, or his fellow PCs throw him out of the party, or worse.
Everything he/she summons, never goes away. So you'll have to figure out what the heck to do with that dire bear or fire elemental once it's done fighting the orcs for you. Eventually a caravan of bizarre creatures either annoyingly ends up following the summoner around, or they go off to cause mayhem elsewhere. Bad news for the poor spell-caster regardless.