There are ruins, scattered about the world, and all are sealed with unbreakable locks.
When all of these locks suddenly open, what emerges?
A cave with weapons sunken into the walls, blades sticking out of the floor and ceiling, and so on. Possibly, any weapon used in it could be torn out of the hand and sink into the stone.
The PCs come across a town with a strange curse: Every morning, those who have grown up here wake up with the memories of someone else. They do not find this strange and have no idea it is happening. They calmly wake up and start these new lives as though they have always been that way.
The cause: A wizard who lived there was spurned by a maiden he was infatuated with. His attempt to manipulate her memories into believing they were already together and that she loved him went horribly awry.