When running a new party, get around the question of plot density by having the first discovery to be a deck of fate, or whatever you call it. If you use a real deck, you should definitely stack it to have the desired outcome, which is to curse the party to attract weird things to happen and involve them. This should not be told to the players at the time, so that they won't just up and try to get themselves 'decursed'. Though quite why they would want to is beyond me.
The blood of a dragon is vital in the creation of potions of longevity. The liver could used to cure any disease or ailment, while the heart could restore a PC to full and complete health, despite their age, or injury.