The PCs have been traveling for a long time down the same stretch or round with no sign of anything suspicious. As they cross over to the next hill they see a gigantic splater of blood with a bleached dragons scull in the center of it. It the dragon skull's mouth is a tattered backpack with something wiggling inside of it.
The characters are given the task of transporting a flask of highly volatile liquid a long distance. The flask cannot be shaken too much or it will explode. The adventure involves stormy sea-voyages, bumpy cart rides through densely populated towns and horseback combat. In short there are many opportunities for it to break and explode.