The PCs have been traveling for a long time down the same stretch or round with no sign of anything suspicious. As they cross over to the next hill they see a gigantic splater of blood with a bleached dragons scull in the center of it. It the dragon skull's mouth is a tattered backpack with something wiggling inside of it.
Made from the tears of a bound goddess, this magical wine has the power to charm or dominate any who imbibe even the faintest quantity. Once affected, it remains dormant until the victim hears a special magical phrase, upon which they will be magically bound to the speaker. Enterprising villains could drop this into the water supply of an important city..