I can explain it better.
A plot is the story of what happens.
A setting is the place where something happens.
Just kidding, but I can use a dictionary:
plot: Any scheme, stratagem, secret design, or plan, of a complicated nature, adapted to the accomplishment of some purpose, usually a treacherous and mischievous one; a conspiracy; an intrigue;
setting: arrangement of scenery and properties to represent the place where a play or movie or rpg is enacted -- The arrangement of performers and properties on a stage for a theatrical production or before the camera in a film. -- A stage setting. -- Physical environment; surroundings.