Was it before, or after I managed to starve to death by standing in one spot for 40 thousand turns, too busy to deat because I was fighting? You know it's a bad sign that you don't get a chance to take a step forwards after breaking a wand of death over your knee in a deliberate attempt to create a self centered ball of death spell. Rodney shall burn for that, I swear it!
Anyway, beyond Kassil's little list, every class has a unique little trick. Some are better than others. Tourists, for example, are generally considered the game's 'hard' mode. Some classes start with stuff pre-identified, others don't. If you want to actually ascend, paranoia is key: I always seem to get impatient. Each class has a unique Quest, and an artifact associated with it. Like the knacks, some Artifacts are better than others, but all of them are useful.
This is not a game you should feel guilty about reading spoilers for. A long time ago, GameSpy made a comparison between Diablo and Nethack that resonated rather well with me. Diablo is the back-yard kiddy pool to Nethack's Marianus Trench. This is what happens when a game is supported for 15+ years. And always remember.. the Devs have thought of everything.