"She sails up'n'down the Tristis River. All them river folk see her an' give her a wide berth. Superstitious lot, them river folk. 'Course, we adventurers kill of monstrous superstitions of the rich type on a daily basis! Who're we ta judge? So's anyways, she is said to only appear when the moon is full and the werewolves howl. And though she's ne'er violent, you can always 'ear a moanin' sound. I got no idea what's aboard that ship, but whate'er it is, I want nothin' to do with it."
-Old Gerald, man in the pub
"The shipyards, a good place to move illict cargo or lay low for a while, but that ship yard in Philly, it's not a place you want to frequent, not if you wish to keep yer skin on anyway."
A city location with a slight horror slant, suitable for any modern day horror/action setting.
A plague has hit the local area.
In humans it affects only the most vulnerable, the children and the very old, and even than it's little more than a summer cold. 24 hours of sniffles and then it's gone, barely noticeable really.
To sheep however it is fatal and the whole economy of the area is in serious trouble. If this keeps up the area could well be facing famine.
Somebody (enter the PCs) must find the rare herbs needed to make a cure.