"She sails up'n'down the Tristis River. All them river folk see her an' give her a wide berth. Superstitious lot, them river folk. 'Course, we adventurers kill of monstrous superstitions of the rich type on a daily basis! Who're we ta judge? So's anyways, she is said to only appear when the moon is full and the werewolves howl. And though she's ne'er violent, you can always 'ear a moanin' sound. I got no idea what's aboard that ship, but whate'er it is, I want nothin' to do with it."
-Old Gerald, man in the pub
"The shipyards, a good place to move illict cargo or lay low for a while, but that ship yard in Philly, it's not a place you want to frequent, not if you wish to keep yer skin on anyway."
A city location with a slight horror slant, suitable for any modern day horror/action setting.
Teenagers who run away from home to live in the wilderness may become feral. As they become more and more feral, they gain some supernatural powers (a la Peter Pan - ability to fly, things they imagine come true - possibly quite powerful), but at the expense of their humanity and ability to speak, comprehend complex subjects, etc. Maybe they have a leader: the most feral of them all.
A regression into a fantasy childlike state.