The Fleabirds are a group of people indigenous to North America who have rejected the collectivism and sedentary lifestyle inherent in the Cosmic Era. Rather than living in the gleaming arcologies, steaming geofronts, or the great heaps of the urban rims and favelas. Rather, they live in caravans that travel the countryside of the continent.
The local band of 'nasties' (goblins / orcs / whatever) lives in relative peace with the local population.
Along come the PCs and go through their usual heroic monster bashing routine, wiping out the nasties and pinching all their stuff, then continue on their way.
Problem is, they don't kill ALL he nasties. The survivors want revenge and, after spending a few months recovering, start to take it in their own inimitable style (which is not unlike that of the PCs come to think of it).
Next time the PCs are in the area they find themselves VERY unpopular with the townsfolk.