They're doing it, they're really doing it
It is easy to assign Autobot and Decepticon like race or nationality, when it is much more a matter of political pursuasion.
More than one convoy crossing the Southwest, traveling through the Republic of Texas and Rocky Mountain Republic has found themselves in the crosshairs of a heavy black transfer truck and it's deranged driver.
Everyone had the nerve to look surprised when the androids starting forming their own society, and started telling humans to stick it, including calling them 'false men'.
Transformers RPG: Rules for Driving and Flying, Rules for Skill checks and skill Descriptions
This was the big leap. I think we are ready for play testing.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...