In the Cosmic Era, the proliferation of arcanotech, cyborgs, robots, parapsychic threats, black market weapons, new illegal drugs constantly hitting the market, all backed up by large organized criminal syndicates, the average police officer doesn't stand a chance.
A village where everyone goes blind sometime during puberty. What could be causing this? Perhaps something in their diet. Or some malignant gene. How would an entire village where only young childen can see function?