Often PCs get on the wrong side of powerful users of magic or break into enchanted tombs, either may get them on the wrong side of a curse.
A world where, instead of aging in years, the people age in knowledge. So, instead of dying once a general age was reached, they die once they achieve a certain amount of knowledge. A man could live forever if he never learned anything, or could die after reading a few choice books. Of course, the knowledge of the land would be regulated, like medical drugs.