In the Cosmic Era, the proliferation of arcanotech, cyborgs, robots, parapsychic threats, black market weapons, new illegal drugs constantly hitting the market, all backed up by large organized criminal syndicates, the average police officer doesn't stand a chance.
In a small inn (the more remote the better), a man turns up dead. There are no wounds on his body what-so-ever, and he aboslutely reeks of garlic.
The man died of a curse that forced him to eat a clove of garlic a day or suffer the penalty. This gets really interesting if the body somehow appears on top of a someone the villagers are suspcious of.