Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
My issue with modifying/removing dwarves and elves is that the PC’s may want to play them.
One of the most powerful tools found in the World Building 102b article is the Worksheet. Here is a place to put the settings you might make with them.
The lengthy process to do something necessary or a magical scroll needed is inscribed on the other side of a great tapestry and can't be removed. For more fun it could be in the kings throne room. Try to hide in shadows with a 20*5 (yards/meters) monstrosity!