Elephants crossing the seas!
It is not an infectious disease, but it is a plague upon the world.
For it spawns villains. And not your garden variety villains, but epic villains, master villains of the most dangerous kind Evil Geniuses.
Pnathic sorcery has existed for ages, crudely used by magi who no idea the true forces they were fumbling with.
An article concerning the nature and role of druids in an RPG enviroment.
Of creatures great and small
The Omen Plague has other names. It is known as The Star Plague and even The Mundane Plague. It is still with us today, now known by the common name of the Shaking Death. To set the stage, the stars were aligned in all the wrong signs. Everyone new something bad was going to happen. When winter set in hard and early, they thought that was it. They were wrong.
Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
Herbalist in the group mistakes one plant for another and mistakenly poisons the group. Not to death, but pretty darn ill with recurring symptoms until the cause and cure are realized. (Local people may be able to help rather easily. "You ate Dragon's Rot you fool, looks and smells just like mint except it has these small thistles on the root. Only grow in the Hornwood Forest, that must be where ya got them. Eat this and you will feel better in 4 hours."