Elephants crossing the seas!
It is not an infectious disease, but it is a plague upon the world.
For it spawns villains. And not your garden variety villains, but epic villains, master villains of the most dangerous kind Evil Geniuses.
Pnathic sorcery has existed for ages, crudely used by magi who no idea the true forces they were fumbling with.
An article concerning the nature and role of druids in an RPG enviroment.
Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
Certain trees have sap that is filled with magical potential. Their sap is harvested and distilled down to produce various types of potions, much like maple syrup is collected in some areas. The magical effects of these syrupy potions are often fairly trivial; perhaps they simply cause the imbiber to grow hair more quickly, summon butterflies, or walk a few inches above the floor. People enjoy the syrup as a flavoring, instead of imbibing it for its magical powers.