Elephants crossing the seas!
It is not an infectious disease, but it is a plague upon the world.
For it spawns villains. And not your garden variety villains, but epic villains, master villains of the most dangerous kind Evil Geniuses.
Pnathic sorcery has existed for ages, crudely used by magi who no idea the true forces they were fumbling with.
An article concerning the nature and role of druids in an RPG enviroment.
Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
"...the Ilthian mountains. A craggie masse of rock rysing from the Ilth'n plaines. The waters whych springe from it are ful of godeness and fortyfie those who drynk them [+1 STR]. Alas the vyle beasts resydent in these hills also bathe in these waters, and in the doing gain great strength. Foes mortallie wounded have bene known to flee, onlie to return, revytalised houres later..." - Chronicler Eamusil, Mondopedia, Vol XV (The Lands of Sylmen)