The mind of a wizard is more open to the more esoteric elements of his surroundings Ã¢â?¬â?? this is why he is able to perceive the weave of the Great Tapestry that is the multiverse, and pull at the strings. This increased sensitivity can manifest in several ways.
If a creature is transformed into another creature (say, a human into a dog), then that creature will become more and more accustomed to the new form until a point is reached where reversing the spell is impossible. A second transformation is possible, but the creature will have to go through the whole process again.