The Doomseekers are a faction within the House of the Forsaken that have as their goal the creation of a biological Doomsday weapon
A loose organization of those touched by the elemental plane of Smoke to combat the PCs
The Floating World, the domain of the Hikikomori
The PCs are stuck in a town with a strict peace policy, the tiniest scuffle can land you years in prison. The town also happens to be a tourist haven, so inn-prices have skyrocketed. The only way the PCs can rest is if they splurge on a room, with their enemy.