An explorer gone missing. A king in panic. A treasure to find.
Welcome to the Craggy Peaks. We hope you don't freeze to death.
That would mean we couldn't... play.
A town is besieged by a changing culture and is desperate to hold on to its oldways. But that gets harder as the next generation starts to leave the traditions behind. The drive of some people to resist change and hold on to what they have is so great that they will not only fightthe undead but eventually embrace them.
An elder cleric asks the PCs to transport a relic to a nearby city. A simple quest with endless possibilities.
Real World: some Indians in the Amazon treat their eyes with a traditional potion applied with palm leaves. Brutally painful, the drug alters vision, giving the jungle's dense green walls greater texture and dimension. You could adapt this to desert or swamps, or other hard to navigate regions.