"Uncle Humblestaff?" the young hero responded. "Of course I know the man. Wouldn't have had a chance at the academy without a word from him. He's the big guy over there, surrounded by all those adventurers."
The only remnant of the Shattering, Lydecker Cain found himself the solitary survivor of a universe that was no more than shards of glass.
"Have you ever felt like there’s a world just beyond ours? Some sort of strange dimension, a light dancing just beyond our fingertips? Well, I’ve touched that ‘sacred’ world, and I know its true face."
History is full of interesting and exotic people who can help to populate your world. They can help illuminate the range of what people think is possible for your world (or you can consider them PCs run by players not in your game).
A plague has hit the local area.
In humans it affects only the most vulnerable, the children and the very old, and even than it's little more than a summer cold. 24 hours of sniffles and then it's gone, barely noticeable really.
To sheep however it is fatal and the whole economy of the area is in serious trouble. If this keeps up the area could well be facing famine.
Somebody (enter the PCs) must find the rare herbs needed to make a cure.