"Reills. E'en the name makes me shudder. That there is unholy ground, cursed by most gods. Not even the demons and devils and the incarnations o' evil dare step foot there. Reills. You know me, I think money likes it in my pocket instead of wherever else it is. But, and I've heard rumors that say this, if theirs treasure on that ground, it ain't going in my pocket on pain o' death."
-Old Gerald, man in the pub.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...