Felim collapsed into the snow, exhausted. It felt like it would be the last fall this time, his limbs stiffening and flesh numb. The adventurer had heard of natives that thrived out here, men who slew bears and made coats of seal fur. But who could build anything out here...?
Just as he felt light start to fade, Felim cast his gaze up to see the sky one last time. He was startled - or would have been, if his body had the energy - to see a furred hood and a leathery face with a toothless grin. "Ho there, brother!" it spoke. "You came to just the right place."
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...