The Neo-Soviet marine biomods
Classified as a category 4 threat, the Elib is somewhere between a vampire lord and Godzilla for limits of escalation. Yes, I would consider using a nuclear device to kill just one. I am that sure that I want it dead.
Pirates' many bejeweled rings and piercings actually had a practical purpose - when the pirate or sailor died, the rings could be taken off as payment for a proper burial, saving him from a watery grave. This could be tied into regional culture, or made into a quest (The Pirate's Lost Rings, etc.). Also gives treasure-seeking divers another thing to look for besides crusty old chests.