The Neo-Soviet marine biomods
Classified as a category 4 threat, the Elib is somewhere between a vampire lord and Godzilla for limits of escalation. Yes, I would consider using a nuclear device to kill just one. I am that sure that I want it dead.
Animals have parasites and diseases, so do plants, there are even bacteria that cann dissolve oil spills or plastic or what have you - why couldn't there be a disease living off magic - a magic item could be infected, losing power and speading the plague to other equipment it contacts, while a magic user would slowly lose his powers and contaminate all he works with or casts a spell at...