Classified as a category 4 threat, the Elib is somewhere between a vampire lord and Godzilla for limits of escalation. Yes, I would consider using a nuclear device to kill just one. I am that sure that I want it dead.
The characters are given the task of transporting a flask of highly volatile liquid a long distance. The flask cannot be shaken too much or it will explode. The adventure involves stormy sea-voyages, bumpy cart rides through densely populated towns and horseback combat. In short there are many opportunities for it to break and explode.