In the desolate wastes of Antarctica, under thick layers of ice and snow, forgotten by the world and only remembered in a few databases of the ancients: There lies Psilabs; a major research complex into the human psyche and the powers of the human mind.
"The wind-driven snow parts for the barest of seconds, revealing a glimpse of refuge from the deadly storm. It’s a massive sapphire pyramid. Yet you know of nothing like it in this area…"
An alchemist enchanted his equipment to produce even more powerful alchemical compounds, potions and the like. Unfortunately, it is not well-known that he had different sets of equipment for different processes: If the wrong set of gear is used, the result will invariably fail to function. It's not a cursed item, just something that's hard to figure out.