Often PCs get on the wrong side of powerful users of magic or break into enchanted tombs, either may get them on the wrong side of a curse.
Many roleplays are set in a world where much of the land is held by barons and other nobles serving under the King or Queen. Sometimes the PCs may need to meet these nobles to ask for help in their Quest, at other times they may be caught for breaking the law and end up with their lives in his hands. Yet nobles are different;some may be good people who care for those underneath them and are loved in return, others may be unpleasent tyrantts hated and feared by their underlings, and still others a bit of both. With this in mind I present thirty nobles
In nature, for instance, a rhino has flies and ticks etc, that live on the hide and live off the blood. Rhino will visit and lie in ponds where turtles will clean the underwater portion of the ticks and a species of bird will clean the the top of ticks and other parasites. What if where the characters camp there were a species of animals that lived off wounds of the creatures. PCs camp. Anybody with wounds on there body are soon covered with small rodent - insect - shadows - whatever. Would immediately see it as a threat I would imagine. But perhaps one of the wounded didn't wake up when it happened, and when they did finally wake they were completely healed. Perhaps somebody was warned of something attacking them but they were able to notice that the wound was actually getting smaller instead of larger. Or maybe they successfully beat the creatures off them and don't notice an improvement, marking this place never to rest at ever again....later learn that villagers send their wounded there but they keep it a guarded secret because they don't want all the attention or traffic and what comes with such a special gift. Could turn into something more too if characters decide to start blabbing about it.