Elephants crossing the seas!
It is not an infectious disease, but it is a plague upon the world.
For it spawns villains. And not your garden variety villains, but epic villains, master villains of the most dangerous kind Evil Geniuses.
Pnathic sorcery has existed for ages, crudely used by magi who no idea the true forces they were fumbling with.
An article concerning the nature and role of druids in an RPG enviroment.
Of creatures great and small
The Omen Plague has other names. It is known as The Star Plague and even The Mundane Plague. It is still with us today, now known by the common name of the Shaking Death. To set the stage, the stars were aligned in all the wrong signs. Everyone new something bad was going to happen. When winter set in hard and early, they thought that was it. They were wrong.
Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
There are reports of a monster that lurks in the tops of trees and drops down on unsuspecting people. It causes them no damage but it frightens them with a hide-like face with big dead eyes, drooling and barking like a dog while unsuccessfully attempting to have intercourse. The PCs investigate and find that it is the local village moron that is doing the spelunking in the woods. How can they explain this otherwise pleasant and merry man that it is wrong to put on a mask, drop down from trees and attempt intercourse with relatives and neighbours.