The Lillith Virus, named for Adam's first wife, was first found in an ice core sample from Antarctica. It's spread through the human population was rapid.
A primitive sibling of EDS, Electromagnetic Sensitivity is a rare affliction that grew to prevalence in the late Petroleum Era, and persists into the Cosmic Era. What was formerly a psychosomatic form of hypochondria is a recognized, and paradoxically, officially discredited disease.
Of creatures great and small
The Omen Plague has other names. It is known as The Star Plague and even The Mundane Plague. It is still with us today, now known by the common name of the Shaking Death. To set the stage, the stars were aligned in all the wrong signs. Everyone new something bad was going to happen. When winter set in hard and early, they thought that was it. They were wrong.
A PC Conjurer or summoner, basically any mage whose sole purpose in life is summoning creatures to aid in battles and various situations, is cursed with a hex, and needs to find a way to undo the curse...before he goes mad, or his fellow PCs throw him out of the party, or worse.
Everything he/she summons, never goes away. So you'll have to figure out what the heck to do with that dire bear or fire elemental once it's done fighting the orcs for you. Eventually a caravan of bizarre creatures either annoyingly ends up following the summoner around, or they go off to cause mayhem elsewhere. Bad news for the poor spell-caster regardless.