Elephants crossing the seas!
It is not an infectious disease, but it is a plague upon the world.
For it spawns villains. And not your garden variety villains, but epic villains, master villains of the most dangerous kind Evil Geniuses.
Pnathic sorcery has existed for ages, crudely used by magi who no idea the true forces they were fumbling with.
An article concerning the nature and role of druids in an RPG enviroment.
Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
"Yn these landes, theye do ryde upone greate flowtinge beastes alike as those thate ye fyshermen do calle nawtilus; Ande these beastes, callede 'pyky-pyky' because of ye noises thate the beastes make, are troubelsome ande beastlye mountes, withe fowle temperes." -Telliamed ap Ynris, "Ye Westerne Landes".
(A levitating giant nautilus that makes a noise like "piki-piki" and is thus called a Great Piki-piki.)