A dangerous, alien plane where glowing frog-slimes slither and slurp, metal-skinned bird people rebuff diplomacy, and only the endless subterranean tunnels are safe (just mind the gravity-bending moles). Visitors will have to skulk around in the dark to avoid the curse carried by the sunlight. Because (have I mentioned?) the sun is the source of a powerful curse--one that covers the whole planet.
What if potions and tonics had negative side effects? Potions of increased strength cause violent tempers, or damage joints. What if potions of dexterity caused tremors, or palsy?
What if they were addictive, and had withdrawal symptoms?
Could someone make a bad batch? No one use the brown strength potion!