The Neo-Soviet marine biomods
Classified as a category 4 threat, the Elib is somewhere between a vampire lord and Godzilla for limits of escalation. Yes, I would consider using a nuclear device to kill just one. I am that sure that I want it dead.
I once read a book about a group of people who discovered a hidden temple city in a mountain range, where the Incas-the ancient civilisation of Peru- had fled to when the spanish invaded. When this group found the burial chamber of one of the inca high priests, they unleashed a powerful curse upon them all...