The Neo-Soviet marine biomods
Classified as a category 4 threat, the Elib is somewhere between a vampire lord and Godzilla for limits of escalation. Yes, I would consider using a nuclear device to kill just one. I am that sure that I want it dead.
An insignficant little species, the candlebug (or waxmoth) is a persistent bane for mages and merchants alike. Each the size of a small digit, these little scarabs thrive on wax and burrow up inside candles, ruining them. Sometimes a late-night worker will hear a crack and a sizzle as his candle expires, only to find the half-burned remains of a waxmoth squirming around on his desk. This is very annoying in worlds where candles are expensive...