This is a great article posted on another site (who reposted it from another site, who took it from another), but I thought many would enjoy it here. It is The Lazy Man’s Guide for Constructing a Call of the Cthulhu Adventure, written by Sandy Petersen, original author of the Call of Cthulhu.
Just off the road a man lies dead, pierced through the heart from behind by an expertly thrown and ornate dagger which remains in the body. A long strip of cloth torn from the man's shirt has been tied around his neck; on the tag end an unknown hand has written a cryptic inscription: "For Djaygo."
When you get to the next town, everyone is talking about a mercenary woman found slain in exactly the same fashion in her room at the inn where she was staying.