Very interesting concept for keeping powerful magic items to a rare minimum. I for one love magic when it comes down to steep penalties and this is one of them. The technology theme behind it, while not working for me, doesn't bother me as I can remove it on my own and implement some form of curse, spiritual denizen or other such nasty affect that could be explainable with some research and enough deaths.
Terrific concept, and makes perfect sense ... heck, some of the armchair theorizing about "mithril" and other fantasy metals have had them come from the transuranic "island of stability."
Beyond that, what's "technological" about this? Radiation is a naturally occurring phenomenon. Uranium is a naturally occurring metal. No one would call rules for what happens when a character is struck by lightning "technological," however much electricity is ubiquitous in our modern world.