Creates a great atmosphere. It would be a long, difficult trek up the mountain. I see Nobody's point. Although on the trek down, carrying all the heavy items, they would have to slowly ditch the treasure as the moved in order to survive. Will give them great grief when their only rope can only hold one person and they have a trench to cross. Each can only keep a handful. It can be worked.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...
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