Simple, little flair, and a definite "Here's an idea to give to the annoying player who is greedy!" award.
Cheka had a good thought for a plot hook. How about one of the player character's picks the pocket of the owner of this unlucky gem thinking he is himself very lucky to have acquired it.
Or perhaps the players have been hired to frequent the locked stash of a local and grab a few of his belongings, one of which is the gem that they just can not get rid of. This could have not only the original owner after them but the one who hired them could also be after them for' not giving up the whole treasure so to speak.
Good idea. So what happens if someone gets both of them? Matter / antimatter annihilation? (just like the way that sounds, probably doesn't apply)(sorry for the aside there...)
Maybe these two orbs are 2 halves of a single orb? And if you have one you have a vague idea where the other is (and whether the other is getting closer). Thus if you've got the crappy orb, you stop every thing to find the good one to discharge the curse. Meanwhile, Mr. Lucky is doing everything he can to KEEP his orb, and getting the heck away from the other poor slob. Might make for interesting background or plots.
More Types of "Special" Creature Blood
Giant Blood - Like Dwarf Blood, the Blood of a massive, thick, and muscular humanoid makes for an excellent addition to any ward or protective spell. It is also known to be useful in size alteration Magic, specifically making things bigger.
Unicorn Blood - Ah, yes. The sacred Unicorn whose Blood is as legendary as the beast itself. To use the Blood of such a pure being you would have to be wholly and completely corrupted and evil, or you soon will be, at the very least.
The Blood of such a noble and majestic creature, be it Unicorn or something else, typically weaves a dark undercurrent into the Magic is is used with. The spells effects can be increased seven-fold, but nothing without a dire cost to your physical ,spiritual, and mental health. The darkness will linger in all the magic you use, a boon, yes, but anyone viewing one of your spells will likely notice you for the foul creature you really are. It is not hard to see such blatant vileness and lust for quick power.
If the blood of a Unicorn is given freely, a tremendously rare event, I imagine these downfalls would be waved, but one can not be sure. Lust for power is, after all, a corrupter itself.
Aberrant Blood - What is an Aberrant? A creature so horrendously horrid that it rots your very mind to ponder its unnatural existance. Likewise, Aberrant Blood is useful in the magic of trickery and illusions that befuddle the mind and leave it weak and supple. Easier to be molded as desired. Very bad stuff, indeed.
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Plant Blood - Yes, it is sap that I speak of. Or other fluids found in plants, being a mixture of water and natural, positive (unless somehow corrupted) creation. These "Bloods" can be used to empower healing Magics and those of the wilderness and nature, such as plant growth or preservation.