A little advice on magic items reposted from the Runebearer website.
A legendary sword used to hunt enemy leaders.
A legendary sword that might save your life.
A legendary axe—once you are hit, there is no escape.
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...