The players have a chance to cure the plague that has sprouted up upon their travels. Will they choose to do the right thing and help bring health back to the region?
Hidden above an alcove behind a forgotten waterfall could be one of the last intact temples of a long persecuted religious order dedicated to the worship of their water elemental patron.
To be used for the final encounter, find the final treasure, or anything that needs to be hidden away better then normal. Typical “who the heck would ever spend the time making it” but it is fun and a mental challenge for a change.
You find a patch of edible funghi. They taste well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick with pains, vomiting, all the fancy stuff. As a gift or good meal, it could be a cruel joke or to make sure the heroes spend their time focused on the mission. And the fine soup you had in the inn yesterday could have some in.
(Inspired through a real-world fungus. Was really used to cure alcoholism.)