"How far? Ye’ll know ye’ve found Malver’s Way when ye sees the Arch."
Gnomes, fascinated with magic, tried to find a way to safely access it, and instead wound up addicted in the deadliest way.
Thaumatechnology - in a world where straight magic has an unnerving tendency to get the user killed, either by magical catastrophe or by being lynched by an upset mob, this is a much safer form of magical use… Even if it does occasionally explode.
Actually a real-world fungus, just heard about it. A fungus that tastes well and all, no ill effects. UNLESS you consume some beverage, even 3 (three) days after eating it. Then you become really sick, pains, vomiting, all the fancy stuff. Was really used to cure alcoholism. May be a joke or to make sure the heroes spend their time focused on the mission.