"Living in a town that sits on a dimensional nexus can wear thin after a while. It's not so much the crawling shadows, bizarre weather, or late night visitors from places that never existed; but carrying on with your normal life and trying to act like nothing out of the ordinary is going on in your little corner of the world that gets to you."
A small rural town with surreal secrets, that happens to be situated on a dimensional crossroads, suitable for modern day supernatural/mystical/horror campaigns.
"Ye thought the orbital penitentiary around Venus was hard ta endure? That place is a vacation spot compared to Davy's Lockdown! If the guard borgs can't find an excuse ta peel the skin off yer bones and the inmates don't use ya for their bettin pool, the pressures o' bein that far beneath the waves will drive ya to the brink, mark my words!"
An underwater prison with a dark past, suitable for any sci-fi, neo-dystopian, or cyber punk setting.
"The shipyards, a good place to move illict cargo or lay low for a while, but that ship yard in Philly, it's not a place you want to frequent, not if you wish to keep yer skin on anyway."
A city location with a slight horror slant, suitable for any modern day horror/action setting.
The Ark of Eden was created to be humanity’s future, now it is the future of humanity that lies lost in the blackness of space.
A college campus for modern day settings, where things are more than they seem at first glance. (Good for a horror or mystery setting)
When you sleep, your soul briefly returns to the place where it was created/goes to when it dies, and seeks nourishment. Everybody's soul is created with a little link (or you could say a greater entity calls it back) to that place so that it can return easily, but upon death, the soul returns via that and annihilates the link as if returns.
Also, as an added thingy, you could say the entity supplying the link, or residue of the links themselves, (whichever) is the source of all arcane power.