"Pass me the blue one." said Quinn.
"Are you sure?" asked Elise. "It's just, you were sure about the last two combinations, and that ceiling got closer both times."
"It's a gamble, I agree," replied Quinn, "but whatever's behind this door has got to be worth it."
Elise passed Quinn the blue stone which he placed carefully in the final slot. As the grinding began, Quinn looked to the door while Elise looked up...
The local band of 'nasties' (goblins / orcs / whatever) lives in relative peace with the local population.
Along come the PCs and go through their usual heroic monster bashing routine, wiping out the nasties and pinching all their stuff, then continue on their way.
Problem is, they don't kill ALL he nasties. The survivors want revenge and, after spending a few months recovering, start to take it in their own inimitable style (which is not unlike that of the PCs come to think of it).
Next time the PCs are in the area they find themselves VERY unpopular with the townsfolk.