"Pass me the blue one." said Quinn.
"Are you sure?" asked Elise. "It's just, you were sure about the last two combinations, and that ceiling got closer both times."
"It's a gamble, I agree," replied Quinn, "but whatever's behind this door has got to be worth it."
Elise passed Quinn the blue stone which he placed carefully in the final slot. As the grinding began, Quinn looked to the door while Elise looked up...
"What do you mean the vault is empty?!"
"Just that, sir. It's empty."
"There was a half tonne of gold coins in there! Did you see a cart? Any orcs or ogres? A dragon?! It's not like it just got up and walked away!"
The adventurers hear a noise and turn, only to see a bottle clatter down the street. Shrugging it off, they continue on their way, blissfully unaware of the hulking mass of junk taking shape behind them...
A PC Conjurer or summoner, basically any mage whose sole purpose in life is summoning creatures to aid in battles and various situations, is cursed with a hex, and needs to find a way to undo the curse...before he goes mad, or his fellow PCs throw him out of the party, or worse.
Everything he/she summons, never goes away. So you'll have to figure out what the heck to do with that dire bear or fire elemental once it's done fighting the orcs for you. Eventually a caravan of bizarre creatures either annoyingly ends up following the summoner around, or they go off to cause mayhem elsewhere. Bad news for the poor spell-caster regardless.