"Bavmor could not possibly have known that the flask was incomplete due to the magical method of its creation. Had Bavmor taken an alchemical approach, he would have known that 10 more ingredients have yet to be found."
- Fitchinger the Great
Pick up a pathology/microbiology book, and add the diseases/syndroms to your game. Your players will freak out.
Coughed at? Diphteria. or tuberculosis?
Drunk from a muddy stream? Or just walked through? Well, let us introduce you to schistosomiasis...
Hit by a stream of energy? Too moch mana is ust like too much radioactivity - perhaps all mages could develop cancer early if too powerful...